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Postal Explorer > Publication 52 - Hazardous, Restricted, and Perishable Mail > Appendix C USPS Packaging Instructions for Mailable Hazardous Materials > USPS Packaging Instruction 6E
Sharps (medical waste) and other regulated medical waste, as defined in
346.12 and DMM 601.10.17.2 are mailable provided that all applicable
requirements specified in 346.32c and DMM 601.10.17.7 are met. See DMM
reference.
• Regulated Medical Waste-Sharps, UN3291.
• Regulated Medical Waste, UN3291.
• Each manufacturer (or distributor) of sharps medical waste or other
regulated medical waste container systems must obtain written
approval prior to mailing from the Manager, Mailing Standards, USPS
Headquarters, Washington, DC (see DMM 608.8).
• International Mail: Prohibited.
• Domestic Mail: Permitted only via Priority Mail or First-Class Mail and
in conjunction with merchandise return service.
General
• Only sharps waste and regulated medical waste mailing container
systems approved by USPS Headquarters may be mailed. Approved
packaging must meet all requirements in DMM 601.10.17.7, including a
leakproof primary receptacle, a leakproof secondary containment
system, sufficient absorbent material, and a strong outer packaging.
• Prior to deposit, containers must be properly assembled according to
the approved manufacturer's (or distributor's) preprinted assembly
instructions.

Marking
• Approved outer shipping containers must clearly display the company
name of the USPS authorized manufacturer, the approval number, and
the container ID number.
• Each mailpiece must be clearly marked on the address side with
"Regulated Medical Waste-Sharps, UN3291" or "Regulated Medical
Waste, UN3291."
• Each mailpiece must bear a properly prepared merchandise return
service label held in the name of the authorized medical waste
manufacturer.
• The universal biohazard symbol shown in Exhibit 346.32e must appear
on the outside of the mailpiece.
• Orientation markings (see Exhibit 226) that properly indicate the upright
position of the primary receptacle must be displayed on two opposite
outer side walls of the mailpiece.
• A complete return address and delivery address must be used.
Documentation
• A four part manifest using the format shown in DMM Exhibit
601.10.17.7c3 must be affixed to the outside of each mailpiece. The
manifest serves as the shipping paper. The manifest must be properly
completed and signed by the mailer.
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