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Postal Explorer > Publication 52 - Hazardous, Restricted, and Perishable Mail > Appendix C USPS Packaging Instructions for Mailable Hazardous Materials > USPS Packaging Instruction 2F
A product or preparation in a nonrefillable metal primary receptacle charged
with a nonflammable solution containing biological products or a medical
preparation that could deteriorate by heat may be accepted in the domestic
mail via surface transportation only provided that the item qualifies as an
ORM-D material and all applicable requirements in 342 are met.
• Consumer Commodity.
• Various (see Appendix A).
• International Mail: Prohibited.
• Domestic Mail: Permitted only via surface transportation sent as
Standard Mail or Parcel Post.
Primary Receptacle
• Capacity of the primary receptacle must be 19.3 fluid ounces (35 cubic
inches) or less, pressure in the primary receptacle must be 140 psig or
less at 130° F, and the liquid content of product and gas must not
completely fill the container at 130° F.
• If heated until the pressure in the primary receptacle is equivalent to
equilibrium pressure of content at 130° F, the primary receptacle must
be able to withstand leakage, distortion, or other damage or defects.
• Only one primary receptacle is permitted per mailpiece.

Cushioning Material
• The primary receptacle must be surrounded by sufficient cushioning
material to absorb shock and prevent breakage.
Outer Packaging
• Strong outer packaging that is capable of firmly and securely holding
the primary receptacle and cushioning is required.
• Multiple primary receptacles are not permitted.
Marking
• Each mailpiece must be clearly marked on the address side with
"Surface Only" or "Surface Mail Only" and "Consumer Commodity
ORM-D."
• A complete return address and delivery address must be used.
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